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Course Discription |
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Haematopoietic stem cell (HSC) is a rare population of somatic stem cell that has the self-renewal capacity and continuously replenish all types of mature haematopoietic cells to sustain blood homeostasis in the body throughout the lifespan of the organism. This course aims to introduce students to the basic aspects of HSC biology, including HSCs differentiation (haematopoietic hierarchy), HSCs self-renewal, HSCs survival, HSCs quiescence, HSCs division in the cell cycle, genes required for HSC fate decisions, the HSC microenvironment that is required to maintain stem cells, characterisations of aged HSCs, HSCs purification, HSCs sources, HSCs expansion, in vivo and ex vivo functional assessments of HSCs, an understanding for how HSCs can be applied in basic clinical research and treatments of haematological malignancies, and the prospective outcomes and limitations of HSC therapies. |