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Course Discription |
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This course introduces the students to the fundamentals of toxicology, at both molecular and clinical aspects. It also introduces the general concepts behind poison treatments. The course starts with introducing the student to toxicological terms such as LD50. Then, it moves to describing animal toxicological studies and dose-response curves with a focus on acute and chronic intoxications. Afterwards, the basic pharmacokinetics of toxicants is described such as absorption, metabolism, distribution and elimination, with great emphasis on the last aspect as a mechanism of detoxification.
Part of the course focuses on famous toxicants such as cyanide and carbon monoxide toxicities and their clinical treatment strategies. By the end of the week, every student will present a case study of a drug that caused significant toxicity and how this was managed pharmacologically and clinically.
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